2,500 employees
http://www.appliedmaterials.com/
Applied Materials manufactures systems for processing silicon wafers and other semiconductor products. Austin's division focuses on R&D and manufacturing.
2,400 employees
http://www.att.com/
(formerly SBC Labs, Inc.)
2,300 employees -
http://www.amd.com/
2,112 employees
http://www.seton.net/
2,058 employees
http://www.ni.com/
Fortune magazine has named National Instruments one of the 100 Best Companies to Work For in America for the last five years. My wife worked at NI for over seven years, and we can attest to the fact that they are a great company.
1,995 employees
http://www.txstate.edu/
Texas State University is halfway between Austin and San Antonio on the San Marcos River and boasts a beautiful campus. Formerly Southwest Texas State University, the school was founded in 1899 and offers undergraduate, master's and PhD programs.
1,956 employees
http://www.girling.com/
Girling Health Care is a family business that coordinates with hospitals, doctors and patients to provide professional home health, personal care, hospice care, and homemaker services to those who have been affected by health issues.